An RNA folding method capable of identifying pseudoknots and base triples
نویسندگان
چکیده
منابع مشابه
An RNA folding method capable of identifying pseudoknots and base triples
MOTIVATION Recently, we described a Maximum Weighted Matching (MWM) method for RNA structure prediction. The MWM method is capable of detecting pseudoknots and other tertiary base-pairing interactions in a computationally efficient manner (Cary and Stormo, Proceedings of the Third International Conference on Intelligent Systems for Molecular Biology, pp. 75-80, 1995). Here we report on the resu...
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RNA pseudoknots are important for function. Three-dimensional structural information is available, insights into factors affecting pseudoknot stability are being reported, and computer programs are available for predicting pseudoknots.
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MOTIVATION The function of an RNA molecule is not only linked to its native structure, which is usually taken to be the ground state of its folding landscape, but also in many cases crucially depends on the details of the folding pathways such as stable folding intermediates or the timing of the folding process itself. To model and understand these processes, it is necessary to go beyond ground...
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An RNA molecule is a heteropolymer, consisting of four types of nucleotides—uracil (U), adenine (A), guanine (G) and cytosine (C)—which are linked into a chain by phosphate bonds. The nucleotides then form saturating hydrogen bonds with one another, with A bonding to U and C bonding to G. These bonds cause the RNA to fold up into a stable, three dimensional structure. The structure is further s...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 1998
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/14.8.691